Frequency of seroreactors to Legionella among the patients with pulmonary infections

A prospective study was conducted with patients with pulmonary infections who were consecutively admitted to the three community hospitals in Benghu from July 1986 to May 1987, and to the children's hospital in Nanjing from September 1986 to January 1987. Antibodies to Lpi-8, Lm, Ld, and Lg were measured by the micro-agglutination test. During the study period, 150 adult patients (100 pairs sera) and 212 control healthy people and 110 pairs sera of childhood patients and 173 children without respiratory tract infections were investigated. The diagnosis of legionellosis was based on seroconversion (fourfold rise in titer to greater than 1:32 or static titer of greater than 1:32) and clinical and radiographic features of legionnaires' disease. About 11% legionella infection in hospitalized adult patients with pulmonary infections, and about 5.45% in children with atypical pneumonias.     

小血管套叠粘接吻合法在血液透析者中建立动静脉内瘘的应用

慢性肾病患者常需要建立动静脉内瘘进行透析，常规间断缝合法吻合动静脉难度大、耗时长。为了缩短吻合时间，提高远期通畅率，进行了套叠粘接吻合法建立动静脉内瘘的实验研究，并将这一方法应用于透析患者建立动静脉内瘘的血管吻合。将动脉端套入静脉端，只需吻合两针，用医用胶封闭吻合口。经８个月观察，通畅率达１００％，血流量均超过３００ｍｌ／ｍｉｎ。达到了透析需要。     

共同管综合征———胆、胰管异常汇合

对我院14年来2322例直接胆管造影所发现的27例AJPBD进行研究，27例中胆总管囊肿8例，胆石症9例，慢性胰腺炎4例，胆管炎3例，胆囊癌2例，胰体癌1例。临床表现为上腹痛（92．6％），黄疸（70．4％），发热（48．1％）或Charcot三联症（44.4％）。发病年龄3～60岁（36．9士17．8）。共同管长15～44mm（20.2士5．9）。据胆、胰管汇合形式作者将AJPBD分为三型。值得注意的是本组3例复杂型患病年龄均＜15岁。本组以胆、肠内引流手术效果满意。AJPBD与胆、胰疾病发生、发展密切相关，作者建议用“共同管综合征”来表述这一复杂病理现象。     

Monitoring of serum markers for fibrosis during CCl4-induced liver damage. Effects of anti-fibrotic agents.

Liver fibrosis was induced in rats by repeated peritoneal injections of carbon tetrachloride (CCl4) over a period of 2-11 weeks. Serum procollagen III peptide (SPIIINP), prolidase (SP) and alanine aminotransferase (SALT) levels were monitored during the period of induction. The extent of fibrosis was semi-quantitatively estimated after collagen staining, and the anti-fibrotic effects of 16,16-dimethyl prostaglandin E2 (DMPGE2), colchicine, and zinc sulphate were studied. SPIIINP and SP were increased the first 2 weeks after CCl4 administration and peaked at 6 weeks. Alterations in SPIIINP and SP correlated well to the semi-quantitative histological score of liver sections during the first 6 weeks, and SP was positively related to SPIIINP throughout the whole induction period. DMPGE2 decreased SPIIINP, SP and SALT significantly in addition to a markedly decreased formation of liver collagens. Colchicine had a similar but less dramatic effect, whereas zinc sulphate only reduced SPIIINP without influencing liver damage. In conclusion SPIIINP seems to be a valuable indicator of liver fibrogenesis, and SP may play a limited role in indicating accelerated collagen metabolism in the liver. DMPGE2 obviously inhibited the production of collagens induced by CCl4. Colchicine also had an apparent effect on liver fibrosis, whereas zinc sulphate merely seemed to postpone it.     

白血病患者血清蛋白结合岩藻糖检测及其临床意义

检测28例白血病患者和28名正常人血清蛋白结合岩藻糖(PBF)值,发现急性白血病组血清PBF值明显高于正常对照组,慢粒,慢淋及慢粒急变者PBF值与正常无差异。完全缓解者血清PBF值下降并渐接近正常,复发时PBF值再次升高,提示血清PBF检测可作为观察白血病化疗效果和复发的指标。     

高血压对糖尿病肾病进展的影响(附51例4年随访报告)

51例糖尿病肾病患者分为高血压组和正常血压组。4年来动态观察其血压、血糖、尿微白蛋白排泄率(AER)、肾功能。发现两组间血糖和糖化血红蛋白相差和变化不大。高血压组AER平均值和4年上升幅度均高于正常血压组(分别为P<0.001,P<0.005)。肾功能以1/cr·t~(-1)表示,两组首次肌酐值近似,4年中肾功损失程度按Mitch方法以斜率b表示,两组间差异显著(P<0.001)。提示高血压是糖尿病肾病进展中的危险因素。     

131例小儿心律失常的临床分析

分析1977～1986年因各种疾病住院伴有心律失常病例131份表明:小儿心律失常的发生、病因、预后等方面与成人相比均有其特点。本组原发疾病共计22种,首位是感染中毒性心肌炎,占50.4％。发作类型以单纯性心律失常为最多见,占42.5％。全部病例采用综合治疗,大多预后良好。     

锰超氧化物岐化酶模型配合物的研究

为探索天然超氧化物岐化酶（ＳＯＤ）岐化超氧离子的机理，及用于临床的可能性，我们合成了乳酸、柠檬酸和酒石酸的锰（Ⅱ）配合物作为Ｍｎ－ＳＯＤ的模拟物，用光照法测定了它们的活性，得到了有意义的结果：锰配合物作为Ｍｎ－ＳＯＤ的模拟物，有肯定的活性，其中以乳酸锰配合物活性最高。     

石密的化学成分研究

从番荔枝科植物石密的茎皮中分离和鉴定了一个氧化阿朴啡类生物碱——石密碱(1)和两个木脂素类化合物:(2R,3R)-2,3-二氢-2-(4-羟基-3-甲氧基苯基)-3-甲基-5-(E)-丙基苯并呋喃(2)和conocarpan(3)。其中石密碱为新化合物,化合物(2)和(3)为从番荔枝科植物中首次分得。     

儿童缺铁性贫血白蛋白营养不良状况的探讨

探讨了缺铁性贫血蛋白质营养状况的变化。对85名正常组,20名缺铁性贫血儿童血清前白蛋白及血浆中19种游离氨基酸水平玉测定。结果缺铁性贫血组儿童PAB明显下降,血浆氨基酸含量、必需氨基酸、支链氨基酸;必需/总氨基酸、支链/非支链氨基酸均明显低于正常儿童,提示缺铁性贫血儿童常同时伴有蛋白营养不良状况。